do polygenic risk scores improve cardiovascular risk prediction

Epidemiol., 41 … Conflict of Interest Disclosures: Dr Gupta reported receiving grants from National Institutes of Health (NIH). The overall net reclassification improvement is defined as the sum of the net reclassifications for events and nonevents (eg, –0.012 + 0.032 = 0.02). Our mission: To reduce the burden of cardiovascular disease. The authors concluded that incorporating genetic information into AF risk prediction tools may help to identify higher risk individuals who may benefit from earlier monitoring and personalised risk-management strategies. Subscription will auto renew annually. PubMed  Google Scholar. Aragam KG, Natarajan P. Polygenic scores to assess atherosclerotic cardiovascular disease risk: clinical perspectives and basic implications. PHG Foundation Aug 2019  |  The CHARGE­-AF risk score strongly predicted incident AF and was associated with a ~3­-fold higher risk of AF per standard deviation (SD) (hazard ratio [HR] 2.88; 95% confidence interval [CI] 2.82–2.94). external icon Janssens ACJW, Joyner MJ. PubMed Central  Interleukin-6 receptor pathways in coronary heart disease: a collaborative meta-analysis of 82 studies. 2015;385:2264–71. Nonetheless, it should not be assumed that adding polygenic risk scores in these populations will improve risk prediction. 2012 Aug;223(2):421-6. doi: 10.1016/j.atherosclerosis.2012.05.035. The Ankle Brachial Index for Peripheral Artery Disease Screening and Cardiovascular Disease Prediction in Asymptomatic Adults: A Systematic Evidence Review for the U.S. Preventive Services Task Force [Internet]. Did you know that your browser is out of date? 2020 Aug;21(5):382-398. doi: 10.2174/1389202921999200630145241. Curr Genomics. Prediction of 10-year first CHD events (including myocardial infarctions, fatal coronary events, silent infarctions, revascularization procedures, or resuscitated cardiac arrest) assessed using measures of model discrimination, calibration, and net reclassification improvement (NRI). Exposures: Please enable it to take advantage of the complete set of features! 2010;376:1393–400. Association for Acute CardioVascular Care, European Association of Preventive Cardiology, European Association of Cardiovascular Imaging, European Association of Percutaneous Cardiovascular Interventions, Association of Cardiovascular Nursing & Allied Professions, Working Group on Atherosclerosis and Vascular Biology, Working Group on Cardiac Cellular Electrophysiology, Working Group on Pulmonary Circulation & Right Ventricular Function, Working Group on Aorta and Peripheral Vascular Diseases, Working Group on Myocardial & Pericardial Diseases, Working Group on Adult Congenital Heart Disease, Working Group on Development, Anatomy & Pathology, Working Group on Coronary Pathophysiology & Microcirculation, Working Group on Cellular Biology of the Heart, Working Group on Cardiovascular Pharmacotherapy, Working Group on Cardiovascular Regenerative and Reparative Medicine. (2020)Cite this article. Circ Genom Precis Med. Lancet. Curr Opin Lipidol. Vanderbilt University Medical Center is committed to principles of equal opportunity and affirmative action. Our report, Polygenic scores, risk and cardiovascular diseaseexamines the current evidence for using polygenic scores for risk prediction and cardiovascular disease prevention. 2010;31:667–75. Tada H, Melander O, Louie JZ, Catanese JJ, Rowland CM, Devlin JJ, et al. Cell. Predictive accuracy of a polygenic risk score compared with a clinical risk score for incident coronary heart disease. Part of Springer Nature. A retrospective cohort study of the predictive accuracy of a previously validated polygenic risk score was assessed among 4847 adults of white European ancestry, aged 45 through 79 years, participating in the Atherosclerosis Risk in Communities (ARIC) study and 2390 participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 1996 through December 31, 2015, the final day of follow-up. A Polygenic Risk Score — a genetic assessment that doctors have hoped could predict coronary heart disease (CHD) in patients — has been found not to be a useful predictive biomarker for disease risk, according to a Vanderbilt study published in the Journal of the American Medical Association.. Lead author Jonathan Mosley, MD, PhD, assistant professor of … Samani NJ, Erdmann J, Hall AS, et al; WTCCC and the Cardiogenics Consortium. Genomewide association analysis of coronary artery disease. Eur Heart J. Dr Psaty reported receiving grants from NIH and serving on the steering committee of the Yale Open Data Access Project funded by Johnson & Johnson. JAMA. Importance: Koenig W. High-sensitivity C-reactive protein and atherosclerotic disease: from improved risk prediction to risk-guided therapy. N Engl J Med. https://doi.org/10.1007/s10557-020-07105-7. Importance: Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening. USA.gov. Among ARIC nonevents, 146 were correctly down classified and 27 were incorrectly up classified. 2020;141:624–636. 2019;12:e002481. 2020 Nov;40(11):2738-2746. doi: 10.1161/ATVBAHA.120.314856. Genetic risk was computed for each participant by summing the product of the weights and allele dosage across 6 630 149 SNPs. (HealthDay)—Genetic testing is not better at predicting coronary heart disease risk compared with conventional risk factors, according to a study published in a recent issue of the Journal of the American Medical Association. By Sowmiya Moorthie, Chantal Babb de Villiers, Tanya Brigden, Louise Gaynor, Alison Hall, Emma Johnson, Saskia Sanderson, and Mark Kroese, We are an exempt charity under the Charities Act 2011 and regulated by HEFCE as a connected institution of the University of Cambridge. Get weekly and/or daily updates delivered to your inbox. 2020;323:627–635. The researchers found that the polygenic risk score was associated with 10-year coronary heart disease incidence in both studies (hazard ratio per … Epub 2020 Sep 22. Sugrue LP, Desikan RS. Damask A, Steg PG, Schwartz GG, et al; Regeneron Genetics Center and the ODYSSEY OUTCOMES Investigators. part may be reproduced without the written permission. Addition of the polygenic risk score to the pooled cohort equations did not significantly increase the C statistic in either cohort (ARIC, change in C statistic, -0.001; 95% CI, -0.009 to 0.006; MESA, 0.021; 95% CI, -0.0004 to 0.043). PubMed  JAMA. JAMA. Highlights of Studies in Cardiovascular Disease Prevention Presented at the 2020 American College of Cardiology Annual Scientific Session. Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, et al. J Am Coll Cardiol. Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history. Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome From the Multi-Ethnic Study of Atherosclerosis. Vanderbilt®, Vanderbilt University Medical Center®, V Oak Leaf Design®, Monroe Carell Jr. Children’s Hospital at Vanderbilt® and Vanderbilt Health® are trademarks of The Vanderbilt University. Article  The standard coronary heart disease (CHD) model includes sex, age, 5 principal components, and the binary classifier for low or high risk are based on the pooled risk equations. Eur Heart J. 2017;135:2091–101. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. These findings suggest that a polygenic risk score may not enhance risk prediction in a general, white middle-aged population. The content is provided for information purposes only. 2008;358:1240–9. Lin JS, Olson CM, Johnson ES, Senger CA, Soh CB, Whitlock EP. Coronary heart disease genetic risk score predicts cardiovascular disease risk in men, not women. 2012;379:1205–1213. Here, we provide a short overview of the current research related to the possible application of PRS in clinical routine and critically discuss existing pitfalls, which still limit a widespread utility of PRS outside a research setting. 2019;73:e285–350. Jernberg T, Hasvold P, Henriksson M, Hjelm H, Thuresson M, Janzon M. Cardiovascular risk in post-myocardial infarction patients: nationwide real world data demonstrate the importance of a long-term perspective. Correspondence to Latest developments in genetic research with the conduction of genome-wide association studies have facilitated a broader utility of polygenic risk score (PRS) as a potent risk prognosticator, being strongly associated with future cardiovascular events. A polygenic risk score (PRS) was constructed based on 142 independent genetic variants previously associated with AF in a meta-analysis from the AFGen Consortium. Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. 2017 Dec 1;2(12):1332-1340. doi: 10.1001/jamacardio.2017.4191. Background. https://doi.org/10.1007/s10557-020-07105-7, DOI: https://doi.org/10.1007/s10557-020-07105-7, Over 10 million scientific documents at your fingertips, Not logged in Predictive accuracy of a polygenic risk score-enhanced prediction model vs a clinical risk score for coronary artery disease. J Med Genet. Amongst the 270,254 individuals contributing to the analyses, with a median of over 8 years of follow-up, 12,407 incident AF cases were identified using hospital episode statistics and death registry data. UL1 TR001881/TR/NCATS NIH HHS/United States, R01 HL142856/HL/NHLBI NIH HHS/United States, R01 HL132320/HL/NHLBI NIH HHS/United States, 16FTF30130005/AHA/American Heart Association-American Stroke Association/United States, U01 HG004402/HG/NHGRI NIH HHS/United States, P30 DK063491/DK/NIDDK NIH HHS/United States. Circulation. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Latest developments in genetic research with the conduction of genome-wide association studies have facilitated a broader utility of polygenic risk score (PRS) as a potent risk prognosticator, being strongly associated with future cardiovascular events. Polygenic scores, risk and cardiovascular disease. Conclusions and relevance: Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease. The researchers found that the polygenic risk score was associated with 10-year coronary heart disease incidence in both studies (hazard ratio per standard-deviation increment, 1.24 and 1.38 for ARIC and MESA, respectively); however, the addition of the polygenic risk score did not improve the predictive ability of the pooled cohort equations for either study. Fernández-Friera L, Fuster V, López-Melgar B, Oliva B, García-Ruiz JM, Mendiguren J, et al. Get the latest public health information from CDC: https://www.coronavirus.gov. 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