This subsection of the Names and taxonomy section is present for entries that are part of a proteome, i.e.
Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling. Mol Pharmacol, 40 (1991), pp. This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Alpha-1D adrenoreceptor. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.,This section provides any useful information about the protein, mostly biological knowledge.
. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.,This section provides information on the disease(s) and phenotype(s) associated with a protein.
,This section describes post-translational modifications (PTMs) and/or processing events.
,This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.
,This subsection of the PTM / Processing section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).
,This subsection of the PTM / Processing section specifies the position(s) and the type of covalently attached lipid group(s).
,This subsection of the PTM/processing section describes post-translational modifications (PTMs). 876-883 . They activate mitogenic responses and regulate growth and proliferation of many cells.
It should be noted that while, in theory, two different sequences could The algorithm is described in the ISO 3309 standard. We postulated a direct action of benzodiazepines in modulating alpha(1)-AR function at the receptor level. They activate mitogenic responses and regulate growth and proliferation of many cells. Res. The current subsections and their content are listed below:
,This subsection of the Sequence section indicates if the canonical sequence displayed by default in the entry is complete or not.
,The checksum is a form of redundancy check that is calculated Manual assertion inferred from sequence similarity toi, PaxDb, a database of protein abundance averages across all three domains of life, ProteomicsDB: a multi-organism proteome resource, GlyGen: Computational and Informatics Resources for Glycoscience, iPTMnet integrated resource for PTMs in systems biology context. Systems used to automatically annotate proteins with high accuracy: Select one of the options below to target your search: Select item(s) and click on "Add to basket" to create your own collection here (400 entries max), Pathway Commons web resource for biological pathway data, Reactome - a knowledgebase of biological pathways and processes, Online Mendelian Inheritance in Man (OMIM), neXtProt; the human protein knowledge platform, The Pharmacogenetics and Pharmacogenomics Knowledge Base, Pharos NIH Druggable Genome Knowledgebase, ChEMBL database of bioactive drug-like small molecules, BioMuta curated single-nucleotide variation and disease association database, Domain mapping of disease mutations (DMDM),
Manually curated information which has been propagated from a related experimentally characterized protein.
Updates in the function and regulation of α1 -adrenoceptors. The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.[4]. Cyclic redundancy and other checksumsThis gene encodes alpha-1D-adrenergic receptor. Alternative name(s): Alpha-1A adrenergic receptor. Meanwhile, a beta receptor (beta-adrenergic receptor) is any group of adrenergic receptors found on the cell surface of tissues and effector organs. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. BMY 7378 was the first high-affinity alpha-1D adrenergic receptor subtype selective ligand that provides a clear pharmacological distinction between the alpha-1B and alpha-1D subtypes (Goetz et al., 1995).Electrophysiological data suggest that BMY 7378 is also a partial agonist at the 5-HT 1A receptors … It consists of three highly homologous subtypes, including α1A-, α1B-, and α1D-adrenergic. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. ,
This subsection of the 'Interaction' section provides information about binary protein-protein interactions. Mice with altered alpha(1)-adrenergic receptor (AR) genes have become important tools in elucidating the subtype-specific functions of the three alpha(1)-AR subtypes because of the lack of sufficiently subtype-selective pharmacological agents. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. 2019; 176:2343–2357. Biophys.
Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. MTFRD…GDVNG → MAAALRSVMMAGYLSEWRTP TYRSTEMVQRLRMEAVQHST S (PubMed: KPPSA…RETDI → SHPAPSASGGCWGRSGDPRP SCAPKSPACRTRSPPGARSA QRQRAPSAQRWRLCP (PubMed: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only.